HPV42 E6

Accession: H000078

NC: ACX32351.1

Uniprot: P27229

Protein: E6

Organism: Human papillomavirus type 42

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MSGTSASSQP TLYQLCKEF LTLRNLQIS IWCKKHLTG EVLAYHFKD VVVWRKDFP
         .         .         .         .         .         .
YAACAFCLEF SKICALRHY RSAFWYTVE ETGLLLEEQ IRCALCQKP SQSEKNHHI
         .         .                                        
DTGTRFQFIL QWTGRCTHC GQCVERRLP