HPV32 E6
Accession: H000073
NC: NP_041801.1
Uniprot: P36810
Protein: E6
Organism: Human papillomavirus type 32
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGCAAGTACTTCTGCCTCATCACAGCCAAGTACATTATACCAATTGTGCAAAGATTTT C:60
M A S T S A S S Q P S T L Y Q L C K D F P:20
. . . . . . G:221
GGGCTGACCCTGCGGAATTTACAAATCTGCTGTATTTGGTGTAAAAACCACTTAACCAGT C:60
G L T L R N L Q I C C I W C K N H L T S P:20
. . . . . . G:281
GCTGAAGCGTATGCATATCATTTTAAAGATTTGCACGTAGTGTGGAAGAAAGGCTTTCCA C:60
A E A Y A Y H F K D L H V V W K K G F P P:20
. . . . . . G:341
TATGCCGCCTGTGCCTTCTGCTTAGAATTTTATTCTAAAGTGTGTGCACTGCGACACTAC C:60
Y A A C A F C L E F Y S K V C A L R H Y P:20
. . . . . . G:401
GACAGATCAGCATTTTGGCATACAGTAGAACAAGAAACAGGACTACTGTTGGAAGAACAA C:60
D R S A F W H T V E Q E T G L L L E E Q P:20
. . . . . . G:461
ATAATTCGCTGTGCTATATGTCAAAAGCCTTTATCGCCAAGTGAGAAAGATCATCATATT C:60
I I R C A I C Q K P L S P S E K D H H I P:20
. . . . . . G:521
TATAACGGACGGCATTTCAGATTCATTTTAAATAGGTGGACGGGTCGCTGTACCCAGTGC C:60
Y N G R H F R F I L N R W T G R C T Q C P:20
G:530
AGAGAATAA C:9
R E P:2