HPV31 E6

Accession: H000072

NC: AAA46950.1

Uniprot: P17386

Protein: E6

Organism: Human papillomavirus type 31

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFKNPAERPR LHELSSALE PYDELRLNC YCKGQLTET VLDFAFTDL IVYRDDTPH
         .         .         .         .         .         .
GVCTKCLRFY KVSEFRWYR SVYGTTLEK TNKGICDLL RCITCQRPL PEEKQRHLD
         .         .                                        
KKKRFHNIGG WTGRCIACW RPRTETQV