HPV16 E6

Accession: H000069

NC: NP_041325.1

Uniprot: P03126

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

Sequence&Mutation

         .         .         .         .         .         .　　　　　G:142
atgcaccaaaagagaactgcaatgtttcaggacccacaggagcgacccagaaagttacca　　　　　C:60
 M  H  Q  K  R  T  A  M  F  Q  D  P  Q  E  R  P  R  K  L  P 　　　　　P:20


         .         .         .         .         .         .　　　　　G:202
cagttatgcacagagctgcaaacaactatacatgatataatattagaatgtgtgtactgc　　　　　C:60
 Q  L  C  T  E  L  Q  T  T  I  H  D  I  I  L  E  C  V  Y  C 　　　　　P:20


         .         .         .         .         .         .　　　　　G:262
aagcaacagttactgcgacgtgaggtatatgactttgcttttcgggatttatgcatagta　　　　　C:60
 K  Q  Q  L  L  R  R  E  V  Y  D  F  A  F  R  D  L  C  I  V 　　　　　P:20


         .         .         .         .         .         .　　　　　G:322
tatagagatgggaatccatatgctgtatgtgataaatgtttaaagttttattctaaaatt　　　　　C:60
 Y  R  D  G  N  P  Y  A  V  C  D  K  C  L  K  F  Y  S  K  I 　　　　　P:20


         .         .         .         .         .         .　　　　　G:382
agtgagtatagacattattgttatagtttgtatggaacaacattagaacagcaatacaac　　　　　C:60
 S  E  Y  R  H  Y  C  Y  S  L  Y  G  T  T  L  E  Q  Q  Y  N 　　　　　P:20


         .         .         .         .         .         .　　　　　G:442
aaaccgttgtgtgatttgttaattaggtgtattaactgtcaaaagccactGtgtcctgaa　　　　　C:60
 K  P  L  C  D  L  L  I  R  C  I  N  C  Q  K  P  L  C  P  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:502
gaaaagcaaagacatctggacaaaaagcaaagattccataatataaggggtcggtggacc　　　　　C:60
 E  K  Q  R  H  L  D  K  K  Q  R  F  H  N  I  R  G  R  W  T 　　　　　P:20


         .         .         .         .         .          　　　　　G:559
ggtcgatgtatgtcttgttgcagatcatcaagaacacgtagagaaacccagctgtaa   　　　　　C:57
 G  R  C  M  S  C  C  R  S  S  R  T  R  R  E  T  Q  L       　　　　　P:18

Epitope&Mutation

>H000069_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
······AMFQDPQER(A3)···········································································································································
······AMFQDPQER(A11)··········································································································································
········FQDPQERPRK(A11)·······································································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
············QERPRKLPQL(B7)····································································································································
·················KLPQLCTEL(A*0201)····························································································································
·················KLPQLCTEL(A2)································································································································
························ELQTTIHDIILECVY(A2)···················································································································
·························LQTTIHDII(A*0201)····················································································································
····························TIHDIILECV(A*0201)················································································································
····························TIHDIILEC(B*4801)·················································································································
······························HDIILECV(B*4002)················································································································
································IILECVYCK(A11)················································································································
····································CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
········································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
················································VYDFAFRDL(A*2402)·····························································································
···················································FAFRDLCIVY(B35)····························································································
···················································FAFRDLCIVY(B57)····························································································
···················································FAFRDLCIV(A*0201)··························································································
···················································FAFRDLCIV(A2)······························································································
······················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
··························································IVYRDGNPY(A3)·······················································································
··························································IVYRDGNPY(A11)······················································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·································································PYAVCDKCL(A*2402)············································································
···································································AVCDKCLK(A11)··············································································
······································································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
······································································DKCLKFYS(A24)···········································································
········································································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
··········································································KFYSKISEY(A24)······································································
··········································································KFYSKISEY(B62)······································································
············································································YSKISEYRHY(A1)····································································
···············································································ISEYRHYCY(B18)·································································
···············································································ISEYRHYCY(A1)··································································
···············································································ISEYRHYCY(A11)·································································
·················································································EYRHYCYSL(A*2402)····························································
······················································································CYSLYGTTL(A*2402)·······················································
······················································································CYSLYGTTL(A24)··························································
··························································································YGTTLEQQYN(A24)·····················································
··························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
···························································································GTTLEQQYNK(A11)····················································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
····························································································TTLEQQYNK(A3)·····················································
····························································································TTLEQQYNK(A11)····················································
·································································································QYNKPLCDLL(A24)··············································
·································································································QYNKPLCDL(A*2402)············································
····································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·····································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·········································································································LLIRCINCQK(A11)······································
·········································································································LLIRCINCQK(A3)·······································
·········································································································LLIRCINCQK(A11)······································
························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
························································································································EKQRHLDKKQRFHNI(DR)···················
····························································································································HLDKKQRFH(A3)·····················
······························································································································DKKQRFHNIRGRWTG(DRB1*01)········
································································································································KQRFHNIRGR(DR*07)·············
··································································································································RFHNIRGRW(A24)··············
····································································································································HNIRGRWTGR(A*6801)········
········································································································································GRWTGRCMSC(B27)·······
·········································································································································RWTGRCMSCC(B27)······
···················································································································································SSRTRRETQL(B14)