HPV16 E5
Accession: H000059
NC: KY994539.1
Uniprot: P06927
Protein: E5
Organism: Human papillomavirus type 16
Function
It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu
Mutation
3850-3900
3901-4000
4001-4100
4101-4101
Legend:same sensemissenseinsertiondeletion
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Sequence&Mutation
. . . . . . G:3909
atgacaaatcttgatactgcatccacaacattactggcgtgctttttgctttgcttttgt C:60
M T N L D T A S T T L L A C F L L C F C P:20
. . . . . . G:3969
gtgcttttgtgtgtctgcctattaatacgtccgctgcttttgtctgtgtctacatacaca C:60
V L L C V C L L I R P L L L S V S T Y T P:20
. . . . . . G:4029
tcattaataatattggtattactattgtggataacagcagcctctgcgtttaggtgtttt C:60
S L I I L V L L L W I T A A S A F R C F P:20
. . . . . . G:4089
attgtatatattatatttgtttatataccattatttttaatacatacacatgcacgcttt C:60
I V Y I I F V Y I P L F L I H T H A R F P:20
. G:4101
ttaattacataa C:12
L I T P:3
Legend:gene mutationamino acid mutation
Epitope&Mutation
Legend:mutationepitope
>H000059_E5
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLIILVLLLWITAASAFRCFIVYIIFVYIPLFLIHTHARFLIT
··············FLLCFCVLL(A*0201)····················································
····················VLLCVCLLI(A*0201)··············································
·············································VLLLWITAA(A*0201)·····················
······························································YIIFVYIPL(A*0201)····