HPV11 E2

Accession: H000024

Uniprot: P04015

Protein: E2

Organism: Human papillomavirus type 11

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Sequence&Mutation

         .         .         .         .         .         .　　　　　G:2782
atggaagcaatagccaagcgtttagatgcgtgccaggatcagttgttagaactttatgaa　　　　　C:60
 M  E  A  I  A  K  R  L  D  A  C  Q  D  Q  L  L  E  L  Y  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:2842
gaaaacagtattgatatacacaaacacattatgcattggaaatgcatacgattggaaagt　　　　　C:60
 E  N  S  I  D  I  H  K  H  I  M  H  W  K  C  I  R  L  E  S 　　　　　P:20


         .         .         .         .         .         .　　　　　G:2902
gtattactacacaaagcaaaacaaatgggcctgagccacatcgggttacaagtagtacca　　　　　C:60
 V  L  L  H  K  A  K  Q  M  G  L  S  H  I  G  L  Q  V  V  P 　　　　　P:20


         .         .         .         .         .         .　　　　　G:2962
ccattaactgtgtcagagactaaaggacataatgctattgaaatgcaaatgcatttagaa　　　　　C:60
 P  L  T  V  S  E  T  K  G  H  N  A  I  E  M  Q  M  H  L  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3022
tccttagcaaaaactcagtatggtgtggaaccttggacattacaggacaccagttatgaa　　　　　C:60
 S  L  A  K  T  Q  Y  G  V  E  P  W  T  L  Q  D  T  S  Y  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3082
atgtggctaacaccacccaaacggtgctttaaaaaacagggaaatactgtggaggtaaaa　　　　　C:60
 M  W  L  T  P  P  K  R  C  F  K  K  Q  G  N  T  V  E  V  K 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3142
tttgatggctgtgaagacaatgtaatggagtatgtggtatggacacatatatacctgcag　　　　　C:60
 F  D  G  C  E  D  N  V  M  E  Y  V  V  W  T  H  I  Y  L  Q 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3202
gacaacgactcatgggtaaaagtaactagttccgtagatgccaagggcatatattataca　　　　　C:60
 D  N  D  S  W  V  K  V  T  S  S  V  D  A  K  G  I  Y  Y  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3262
tgtggacaatttaaaacatattatgtaaattttaataaagaggcacaaaagtatggtagt　　　　　C:60
 C  G  Q  F  K  T  Y  Y  V  N  F  N  K  E  A  Q  K  Y  G  S 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3322
accaatcattgggaagtatgttatggcagcacagttatatgttctcctgcatctgtatct　　　　　C:60
 T  N  H  W  E  V  C  Y  G  S  T  V  I  C  S  P  A  S  V  S 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3382
agcactgtacgagaagtatccattgctgaacctactacatacacccccgcacagaccacc　　　　　C:60
 S  T  V  R  E  V  S  I  A  E  P  T  T  Y  T  P  A  Q  T  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3442
gcccctacagtgtccgcctgcaccacggaagacggcgtgtcggcgccgcctaggaagcga　　　　　C:60
 A  P  T  V  S  A  C  T  T  E  D  G  V  S  A  P  P  R  K  R 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3502
gcacgtggaccgtccactaacaacaccctgtgtgtggccaacatcagatccgtggacagt　　　　　C:60
 A  R  G  P  S  T  N  N  T  L  C  V  A  N  I  R  S  V  D  S 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3562
acaatcaacaacatcgtcactgacaattacaacaagcaccaaagaaggaacaactgtcac　　　　　C:60
 T  I  N  N  I  V  T  D  N  Y  N  K  H  Q  R  R  N  N  C  H 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3622
agtgcagctacgcctatagtgcaactgcaaggtgattccaattgtttaaaatgttttaga　　　　　C:60
 S  A  A  T  P  I  V  Q  L  Q  G  D  S  N  C  L  K  C  F  R 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3682
tatagactgaatgacaaatataaacatttgtttgaattagcatcttcaacgtggcattgg　　　　　C:60
 Y  R  L  N  D  K  Y  K  H  L  F  E  L  A  S  S  T  W  H  W 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3742
gcctcacctgaggcaccacataaaaatgcaattgtaacattaacatatagcagtgaggaa　　　　　C:60
 A  S  P  E  A  P  H  K  N  A  I  V  T  L  T  Y  S  S  E  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3802
caacgtcagcaatttttaaacagtgtaaaaataccacccaccattaggcataaggtgggg　　　　　C:60
 Q  R  Q  Q  F  L  N  S  V  K  I  P  P  T  I  R  H  K  V  G 　　　　　P:20


         .         .                                        　　　　　G:3826
tttatgtcattacatttattgtaa                                    　　　　　C:24
 F  M  S  L  H  L  L                                        　　　　　P:7

Epitope&Mutation

Legend:mutationepitope

>H000024_E2
MEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMGLSHIGLQVVPPLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYEMWLTPPKRCFKKQGNTVEVKFDGCEDNVMEYVVWTHIYLQDNDSWVKVTSSVDAKGIYYTCGQFKTYYVNFNKEAQKYGSTNHWEVCYGSTVICSPASVSSTVREVSIAEPTTYTPAQTTAPTVSACTTEDGVSAPPRKRARGPSTNNTLCVANIRSVDSTINNIVTDNYNKHQRRNNCHSAATPIVQLQGDSNCLKCFRYRLNDKYKHLFELASSTWHWASPEAPHKNAIVTLTYSSEEQRQQFLNSVKIPPTIRHKVGFMSLHLL
····AKRLDACQDQLLE(DRB1*0301)···················································································································································································································································································································································
····························································································································································································································································································PIVQLQGDSNCLKCFR(DRB1*0102)························································
····························································································································································································································································································PIVQLQGDSNCLKCFR(DRB1*0301)························································

DETAIL

EPITOPE & MUTATION